MOTS-c
The « exercise mimetic » peptide that activates AMPK.
iThe essentials in 10 seconds
- Natural peptide of 16 amino acids, produced by your own mitochondria
- It activates AMPK — the same pathway as exercise — to boost metabolism
- Energy · blood sugar · fats · muscle · endurance · recovery · anti-aging
- Subcutaneous injection, in cycles of 4 to 6 weeks, under medical supervision
IWhat is MOTS-c?
"Mitochondrial Open Reading Frame of the 12S rRNA, type c": a peptide of 16 amino acids, discovered in 2015 (University of Southern California). Your mitochondria — the "power plants" of your cells — produce it naturally. It acts as a signal sent to the cell nucleus to activate metabolism, exactly as a workout would. Hence its nickname "exercise mimetic": the benefits of effort, in part, without the effort.
Emerging peptide: human data are accumulating (ongoing studies on obesity, type 2 diabetes, metabolic syndrome). Use reserved for a supervised medical setting.
The molecules presented on this site are innovative and fall under experimental use. Human data remain limited: a studied mechanism or a preclinical observation is not sufficient to demonstrate a benefit. The regulatory status in Morocco is not established for most of these peptides. Any use is decided within the framework of a medical consultation, with follow-up — never alone, never without an assessment.
IIThe benefits
Activates AMPK (the same pathway as exercise), stimulates mitochondrial energy production and improves exercise capacity.
Improves insulin sensitivity and helps regulate blood sugar — a central axis of metabolic syndrome and aging.
Increases fatty acid oxidation and supports loss of fat mass, particularly abdominal.
Prevents muscle atrophy and promotes regeneration after exertion.
Supports the NAD+/SIRT1 axis, protects mitochondria from aging and contributes to bone density.
Documented neuroprotective effects: mental clarity and support of cognitive functions.
IIIRecommendations & how to use
Route: subcutaneous injection (abdomen or thigh), on an empty stomach or away from meals · Storage: refrigerated (2–8 °C), protected from light — do not freeze · Schedule: in cycles, never continuously.
MOTS-c does not replace exercise or diet: it amplifies them.
| Dosage | Price |
|---|---|
| 20 mg | Provided on request |
Prices are not published online: they are provided on request, during a consultation or by telephone.
IVThe two protocols
Objective: regain energy, regulate blood sugar, promote body composition and slow metabolic aging.
Monitoring: fasting blood sugar, liver panel, perceived energy level.
Objective: endurance (fat oxidation spares glycogen), faster recovery, body composition.
Combine with: hydration 1.5–2 L/day + sufficient protein intake.
VProtocol rules
- Drink 1.5 to 2 L of water/day
- Maintain physical activity — MOTS-c amplifies the effects of exercise
- Regular sleep: recovery is part of the treatment
- Store vials in the refrigerator (2–8 °C)
- Note your energy and sensations for monitoring
- Do not exceed the prescribed dose or chain courses without a break
- No self-injection without training and medical supervision
- Never mix several peptides in the same vial
- Reconstitution only with bacteriostatic water (never tap water)
- Pregnancy, breastfeeding, active cancer: contraindication — medical advice required
VIYour journey in 3 steps
Metabolic evaluation, objectives, injection training, protocol handover.
Injections according to the chosen protocol (general or sports), monitoring of how you feel.
Assessment, adjustment of dose/schedule, decision on next steps (break, continuation, adaptation).
VIIPublications & references
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitationZheng et al. · Front Endocrinol (Lausanne) · 2023 · PMID 36761202
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceLee et al. · Cell Metab · 2015 · PMID 25738459
- MOTS-c: A Mitochondrial-Encoded Regulator of the NucleusBenayoun BA, Lee C · Bioessays · 2019 · PMID 31378979
Documentary references: the existence of a publication establishes neither efficacy nor safety for personal use. The regulatory status in Morocco must be verified.